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Taken together, evidence from neuroscience, human research, and clinical practice suggests meaningful overlap between obesity and addiction-related mechanisms. Leggio says that his lab has long been interested in how gut-brain neuroendocrine pathways may influence alcohol use disorder (AUD)

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doi:10.1007/s00384-014-2030-8

Fold change abundance and statistical testing were performed using a two sample Welch t-test after log2 plus one transformation of the protein spectral counts to compare expression between PF4 Cre Thbs1 flox and WT mice